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Who is affected?


Sickle Cell Anaemia affects people from most ethnic descendants. Basically, it developed in countries where Malaria (a parasitic infection occurring mainly in the tropics and subtropics) was prevalent [full description below]. This means that Sickle Cell Anaemia affects people from, or who descend from:

  • Africa
  • The Caribbean; and
  • India

Malaria

A parasitic infection occurring mostly in the tropics and subtropics.

Malaria is caused by a protozoan parasite of the genus Plasmodium, which requires two different hosts during its life cycle: man and mosquito. It is transmitted from man to man by the bite of an infected mosquito. The mosquito sucks blood from an infected person, taking in the parasite - which can then continue its life cycle within the mosquito. Later, when the mosquito bites another human, the parasites pass in with the insect's saliva.

Once inside man, the parasites continue to develop in the liver. From there they reenter the bloodstream and multiply inside red blood cells, causing them to rupture within two or three days. This rupture of the red cells is responsible for the characteristic chills, fever and sweating of malaria. Parasites released into the bloodstream when the cells rupture can enter other red cells, and the life cycle is repeated.


Definition from Family Medical Encyclopedia -
Published in 1984 by Book Club Associates